Technology drives biological research. A new technology can instantly provide answers that were difficult or impossible to address using current approaches. The emerging field of proteomics provides researchers an alternative/complementary strategy to...
We are trying to understand how circulating cells manage to leave the blood stream and home to distinct organs or tissues where they may have crucial physiologic functions or may cause disease. Despite considerable progress in this field, it is still...
The Hacohen lab consists of immunologists, geneticists, biochemists, technologists, physicians and computational biologists working together to develop new and unbiased technologies and strategies to understand basic immune processes and immune-mediated...
We use frog egg extracts to study the molecular mechanisms underlying DNA replication and repair, and how these processes go awry in human disease. We are working on the following areas:
1. DNA cross-link repair. Our cells are constantly exposed to...
Our laboratory studies diseases of the gastrointestinal tract, with emphasis on colorectal cancer (CRC) and inflammatory bowel disease (IBD). We use both conventional and systems biology approaches to integrate studies of genetically engineered mouse...
I am Professor of Medicine at Harvard Medical School and Director of Personalized Medicine (PPM) at Partners HealthCare System, where I am responsible for 15 faculty and ~100 staff that work in our Core Laboratories, the Partners Biobank, our CLIA...
There are clear resemblances between parents and children for height, weight, and many other traits and diseases; these familial resemblances are influenced strongly by inherited genetic factors. Most common diseases (such as diabetes, obesity, or asthma...
Our lab's projects lie at the intersection of genetics, neurobiology, and bioinformatics, which we apply to understand (and treat) rare pediatric neurologic diseases.
Autism genetics and neurobiology: We apply whole exome and whole genome sequencing to...