BBS

Our research focuses on the processes that mediate and regulate the movement of membrane proteins throughout cells. In particular our studies have help define molecular mechanisms that underlie the cell's sorting machineries mediated by the clathrin...

Our lab aims to understand the in vivo functions of certain genes identified in neurodegenerative and developmental disorders of the human brain such as schizophrenia, Alzheimer's disease, lissencephaly, autism and mental retardation.  We use a variety...

Hematopoietic stem cells (HSCs) can give rise to each of the blood lineages present throughout a vertebrate’s lifetime. The gene programs and signaling networks regulating HSC development and function in the embryo and adult are highly evolutionarily...

We are trying to understand how circulating cells manage to leave the blood stream and home to distinct organs or tissues where they may have crucial physiologic functions or may cause disease. Despite considerable progress in this field, it is still...

Research in our lab revolves primarily around aging, lifespan control and rejuvenation.

  We also have had longstanding interests in selenium and redox biology.   Understanding mechanisms of lifespan control through longevity signatures   Mice live 3...

Mitochondria are tiny organelles found in nearly all cells, serving as the center stage for ATP production, ion homeostasis, and apoptosis. Their composition, density, and coupling efficiency are dynamic properties, varying across cell types and adapting...

Our laboratory utilizes human genetic approaches to gain insight into blood cell production (hematopoiesis) and how this process is perturbed in disease states. We study rare genetic blood disorders and the genetics underlying variation in hematopoiesis...

The Khurana lab uses stem cells, genomic analysis and systems cell biology approaches to better understand and develop patient-specific therapies for Parkinson’s disease, ataxias and related disorders. The lab has created the first proteome-scale...

The Fontana lab has two main goals. First, understand the dynamical processes that constitute and maintain biological organization in terms of interactions among molecular components. Second, identify those properties of a biological system that are...

Our laboratory focuses on the engineering of human monoclonal antibodies for their use in discovery research and as drugs for the treatment of human diseases. We are working in two broad disease areas: emerging infectious diseases and cancer. We have...