Immunology

Hemostasis and Immunity Laboratory

Our laboratory aims to understand the role of the hemostatic factors (i.e., coagulation and fibrinolytic factors) in regulating inflammation at the mucosal barrier sites. The hemostatic and inflammatory systems have...

The core mission of The Majzner Laboratory is to leverage discoveries in basic immunology and cancer biology to develop and test new immunotherapeutics in children and adults with cancer. Our research program focuses on three core areas: 1) Developing...

The Bod Lab focuses on deciphering the landscape of phenotypic and functional B cell states in inflammatory diseases, in particular cancer. We are interested in exploring which B cell subset is favorable or detrimental for cancer progression, and by...

Rapid advances in gene engineering make the previously unimaginable rapidly accessible. The Smith Lab for Genetic and Cellular Engineering uses synthetic biology to address our missions of: (1) answering pressing questions around the biology of...

The overall goal of my lab is to apply principles of allergic and inflammatory disease pathophysiology in humans to questions at the bench, and in turn to bring fundamental findings made at the bench back to the clinic. A dominant theme is how lipid...

Our laboratory aims to understand the cellular and molecular interactions of the skeletal and immune systems in a relative recent branch of immunology termed osteoimmunology. Osteoimmunology studies the fundamental scientific principles that regulate the...

The Sen laboratory investigates the regulation of T cell dysfunction and explores epigenetic approaches for T cell engineering. We have found that the regulatory “circuitry” of dysfunctional T cells differs remarkably from functional T cells fighting off...

Symbiotic microbiota residing on the body surface (gut lumen, skin and other areas) easily outnumbers our own cells and dwarfs our genome by hundred folds with their metagenome.  Large-scale research projects such as Human Microbiome Project have...

The major goal of the Guerriero lab is to accelerate breast cancer immunotherapy by harnessing tumor associated macrophages. To date, immunotherapy has largely focused on recruiting and activating anti-tumor T cells, which has shown tremendous responses...

Research focus of my lab is to use novel synthetic biology approaches to manipulate conventional and memory-like Natural Killer (NK) cells to enhance their anti-tumor function. Using advanced CRISPR and non-CRISPR based gene editing approaches we are...