Virology

Research in the Howley laboratory is focused on the molecular biology of the papillomaviruses and the role of these viruses in carcinogenesis. Several specific types of the human papillomaviruses (HPVs) are associated with human cervical cancer. The...

We seek to develop and apply technologies (particularly revolving around high-dimensional tissue imaging) to address questions related to host-disease interactions in their native tissue context. By combining these methodologies with a systems approach...

Dr. Corbett uses her viral immunology expertise to propel novel vaccine development for pandemic preparedness, including mRNA-1273, a leading vaccine against SARS-CoV-2. The vaccine concept incorporated in mRNA-1273 was designed by Dr. Corbett's NIH team...

Question
How can we measure the structures of RNAs in the cell? How does RNA regulate gene expression in normal cells, and what aspects go awry in the onset of disease states such as viral infections, neurodegeneration and cancer?

Approach
RNA viruses have...

I am the Director of the Harvard/Brigham Virology Specialty Laboratory and the Director of the Harvard University Center for AIDS Research Clinical Core. My research is focused on HIV and SARS-CoV-2 drug resistance, reservoirs, and viral remission...

 

Dr. Gaurav D. Gaiha, MD, DPhil, is an Assistant Professor of Medicine at Harvard Medical School and Attending Physician in the Division of Gastroenterology at Massachusetts General Hospital (MGH). Dr. Gaiha’s lab focuses on understanding the T cell...

How do cells sharing the same DNA produce drastically distinct phenotypes? In one organism, the same genome allows for the development of different tissues, controlled cell cycle progression, and specialized responses to environmental stimuli. This...

Our body is colonized by a robust and diverse ecosystem - the commensal microbiome. When mucosal pathogens infect us, they first encounter our commensals before they encounter and activate our immune response. The Gopinath lab is interested in the...

We use methods in molecular biology, immunology, and structural biology to study host-pathogen interactions, with the goal of informing strategies aimed at treating or preventing infection.

Several enveloped RNA viruses cause human viral hemorrhagic...

Dr. Bruce Walker is the Director of the Ragon Institute of MGH, MIT and Harvard, a Professor of Medicine at Harvard Medical School, a Howard Hughes Medical Institute Investigator, and a board-certified Infectious Disease specialist. The overarching goal...