Research in the Howley laboratory is focused on the molecular biology of the papillomaviruses and the role of these viruses in carcinogenesis. Several specific types of the human papillomaviruses (HPVs) are associated with human cervical cancer. The...
Question
How can we measure the structures of RNAs in the cell? How does RNA regulate gene expression in normal cells, and what aspects go awry in the onset of disease states such as viral infections, neurodegeneration and cancer?
Approach
RNA viruses have...
I am the Director of the Harvard/Brigham Virology Specialty Laboratory and the Director of the Harvard University Center for AIDS Research Clinical Core. My research is focused on HIV and SARS-CoV-2 drug resistance, reservoirs, and viral remission...
Dr. Gaurav D. Gaiha, MD, DPhil, is an Assistant Professor of Medicine at Harvard Medical School and Attending Physician in the Division of Gastroenterology at Massachusetts General Hospital (MGH). Dr. Gaiha’s lab focuses on understanding the T cell...
How do cells sharing the same DNA produce drastically distinct phenotypes? In one organism, the same genome allows for the development of different tissues, controlled cell cycle progression, and specialized responses to environmental stimuli. This...
Influenza virus in humans evolves in response to pressure from immunity in the potentially susceptible population, resulting in progressive variation of viral antigenicity ("antigenic drift"). Introduction into human circulation of a new serotype from...