# Bruce H. Horwitz Associate Professor of Pediatrics ![Bruce Horwitz](/sites/g/files/omnuum3501/files/styles/hwp_4_5__480x600/public/dms/files/horwitz_bruce_0.jpg?itok=cuycZ_S9) location\_on Brigham and Women's Hospital Enders Building, room 675 300 Longwood Ave. Boston, MA 02115 smartphone [617-525-4404](tel:617-525-4404) email laptop\_windows [Lab Website](https://www.childrenshospital.org/directory/physicians/h/bruce-horwitz) laptop\_windows [Publications](https://pubmed.ncbi.nlm.nih.gov/?term=Horwitz%2C+Bruce+H&sort=date) The major focus of my laboratory is to understand the role of the NF-κB family of transcription factors in regulating innate inflammatory responses. NF-κB is generally thought of as a pro-inflammatory agent. However, work from our laboratory has demonstrated that certain NF-κB subunits inhibit the ability of bacteria to induce inflammation in several models, including mouse models for inflammatory bowel diseases and septic shock. Furthermore, NF-κB subunits also play a major role in limiting the ability of bacteria to induce critical pro-inflammatory genes such as IL-12. One of the mechanisms by which NF-κB subunits appear to inhibit pro-inflammatory gene expression is by facilitating the inhibitory potential of IL-10, a critical product of regulatory T cells. This may explain our observations that regulatory T cells are unable to suppress pathological inflammation in mice that lack NF-κB subunits. Ongoing projects within the laboratory include elucidating the cellular and biochemical pathways by which NF-κB and IL-10 inhibit inflammatory bowel disease, and understanding the role of NF-κB subunits in regulating septic shock. - ## Faculty [Immunology](/faculty/immunology)