# David T. Breault Associate Professor of Pediatrics ![breault_david.jpg](/sites/g/files/omnuum3501/files/styles/hwp_4_5__480x600/public/dms/files/breault_david.jpg?itok=9kxj2LAn) location\_on Boston Children's Hospital Division of Endocrinology, CLS 16026 300 Longwood Ave Boston, MA 02115 smartphone [617-919-2863](tel:617-919-2863) email laptop\_windows [Lab Website](http://breaultlab.org/) laptop\_windows [Publications](https://pubmed.ncbi.nlm.nih.gov/?term=Breault%20DT%5BAuthor%5D&cauthor=true&cauthor_uid=22226346) As a physician-scientist caring for children with chronic disease I am acutely aware of the burden caused by these conditions and the need for improved therapeutic treatment options. Regenerative medicine offers enormous hope for the treatment of many conditions either through the directed differentiation of pluripotent stem cells or through the activation of endogenous tissue stem cells. My laboratory is pursuing various strategies to direct stem cell differentiation and to identify self-renewing progenitor/stem cells from a variety of mouse tissues with regenerative potential. Recent work has lead to the discovery of several populations of slowly-cycling tissue stem cells, including an elusive intestinal stem cell. We are now investigating the basic mechanisms regulating this population, including their response to physiological and pathological stress as well as their role in establishing cancer. - ## Faculty [BBS](/faculty/bbs)