#  Jennifer Guerriero 

Assistant Professor of Surgery

 

 

 



   ![Jennifer Guerriero](/sites/g/files/omnuum3501/files/styles/hwp_4_5__480x600/public/dms/files/guerriero_jennifer.jpg?itok=Ruw84rbj) 

 



 

 location\_on Brigham and Women's Hospital Thorn Research Building 407 20 Shattuck Street Boston, MA 02115 

 email [mailto:jguerriero@bwh.harvard.edu](mailto:mailto:jguerriero@bwh.harvard.edu) 

 laptop\_windows [Lab Website](https://guerrierolab.bwh.harvard.edu/) 

 laptop\_windows [Publications](https://www.ncbi.nlm.nih.gov/myncbi/1Xsuq5pG3v9/bibliography/public/) 

 

 



 

The major goal of the Guerriero lab is to accelerate breast cancer immunotherapy by harnessing tumor associated macrophages. To date, immunotherapy has largely focused on recruiting and activating anti-tumor T cells, which has shown tremendous responses in some types of cancers, but we know that not all patients and not all cancer types benefit from T cell targeted approaches. Macrophages are highly prevalent in solid tumors and function to promote cancer cell survival and proliferation and can also inhibit anti-tumor T cells responses. Therefore, the Guerriero Lab aims to target macrophages to design clinically effective strategies to promote T cell activation and weaken the immune-suppressive tumor microenvironment to improve immunotherapy response rates in breast cancer patients. The lab is particularly interested in identifying tumor-promoting tumor macrophages in breast tumors before and after therapy, elucidating their molecular and metabolic regulation that promotes immune suppression and therapy-resistance and determining how tumor macrophage phenotype, diversity, metabolism and function can be modulated for anti-tumor responses. The lab is working to perform in-depth analysis of animal models and patient samples to efficiently guide rational use and development of immunotherapy modalities for the treatment of breast cancer.

 

 

 





 

 

- ## Faculty
    
     [Immunology](/faculty/immunology)