# Jonathan Strecker Assistant Professor of Genetics ![Jonathan Strecker](/sites/g/files/omnuum3501/files/styles/hwp_4_5__320x400/public/dms/files/strecker_jonathan.jpg?itok=YH11ZpuT) location\_on Massachusetts General Hospital Department of Molecular Biology, Room 7300 185 Cambridge Street Boston, MA 02114 email laptop\_windows [Lab Website](https://www.thestreckerlab.org/) laptop\_windows [Publications](https://pubmed.ncbi.nlm.nih.gov/?term=Jonathan+Strecker) Our lab is broadly interested in the biology of immune proteins found throughout nature. Bacteria have evolved numerous defenses against phage, including CRISPR-Cas systems, and while these predominantly function as RNA-guided nucleases, additional functions exist including CRISPR-associated transposases that perform RNA-targeted DNA insertion, and CRISPR-associated proteases that cleave protein substrates upon RNA detection. We are interested in how cells sense and respond to nucleic acids and how diverse enzymes can be controlled in a programmable manner. Our long-term goal is to use these basic discoveries to enable new functions in biology and to contribute to our understanding of the human genome. - ## Faculty [BBS](/faculty/bbs)