# Ramnik J. Xavier Kurt J. Isselbacher Professor of Medicine in the Field of Gastroenterology ![Ramnik Xavier](/sites/g/files/omnuum3501/files/styles/hwp_4_5__320x400/public/dms/files/xavier_ramnik_0.jpg?itok=9sq0kjVt) location\_on Massachusetts General Hospital Center for Computational & Integrative Biology 185 Cambridge Street - Simches 7222 Boston, MA 02114 Tel: 617-643-3331 Fax: 617-643-3328 Institute Member Broad Institute of Harvard and MIT 415 Main St., 7th Floor smartphone [617-643-3331](tel:617-643-3331) email laptop\_windows [Lab Website](https://molbio.massgeneral.org/labs/xavier-lab) laptop\_windows [Additional Lab Website](https://www.broadinstitute.org/xavier-lab) laptop\_windows [Publications](https://pubmed.ncbi.nlm.nih.gov/?term=Xavier%2C%20Ramnik%5BAuthor%5D) The Xavier Laboratory, spanning the Department of Molecular Biology at Massachusetts General Hospital and the Broad Institute, focuses on systematic characterization of genetic variants to understand the regulation of innate and adaptive immunity; initiation and resolution of tissue inflammation using single-cell and spatial transcriptomics; chemical biology to control and correct cellular disease phenotypes suggested by human genetics; molecular mechanisms that determine the roles of microbes in health and disease; and development of computational approaches to uncover patterns of human and microbial pathway activation during disease and treatment. EXPERIMENTAL APPROACH – \- Spatial transcriptomics \- Development of new technologies to study the immune system \- CRISPR base-editing and genetic screens \- Lysosomal biology \- Microbiome mining \- Computational methods FIELD OF STUDY – \- Autoimmunity \- Genotype-to-phenotype maps \- Gut microbiome function \- Deep mechanistic studies to chemical biology \- Mucosal immunity \- Tissue metabolism - ## Faculty [BBS](/faculty/bbs) [Immunology](/faculty/immunology)