#  Robert Rowe 

Assistant Professor of Pediatrics

 

 

 



   ![Robert Rowe](/sites/g/files/omnuum3501/files/styles/hwp_4_5__480x600/public/dms/files/rowe_robert.jpg?itok=6obaWQvu) 

 



 

 location\_on Boston Children's Hospital Karp Bldg. 7 1 Blackfan Circle Boston, MA 02115 

 email [grant\_rowe@dfci.harvard.edu](mailto:grant_rowe@dfci.harvard.edu) 

 laptop\_windows [Lab Website](https://www.childrenshospital.org/research/labs/rowe-lab-research) 

 laptop\_windows [Publications](https://pubmed.ncbi.nlm.nih.gov/?term=rowe+rg) 

 

 



 

Our laboratory is interested in the intersection of normal hematopoietic development and blood diseases. Our research is rooted in the fundamental observation that adults and children are affected by different blood diseases. We believe that this is due to differences in the properties of the hematopoietic system from which these diseases arise. As such, one area of focus in the laboratory is aimed at understanding both the cell-intrinsic and -extrinsic factors that define the function of hematopoietic stem and progenitor cells (HSPCs) at various ages. We use mouse and human systems to define the molecular mechanisms of HSPC maturation from the prenatal to the pediatric and mature adult states. We use mouse transplantation, xenotransplantation, and heterochronic transplantation models to define the relative roles of intrinsic and extrinsic factors in the HSPC maturation and aging process. The second focus of the laboratory is applying these developmental concepts to blood diseases. Many blood diseases are biased in their age of onset, including bone marrow failure diseases, hemoglobinopathies, and certain subtypes of leukemia. By applying principles of hematopoietic maturation and aging, we have developed novel mouse and human models of leukemia that we are using to understand age-related pathobiology. We also use human induced pluripotent stem cells to model juvenile and adult forms of bone marrow failure and to define factors differentiating these classes of HSPC dysfunction.

 

 

 





 

 

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