The Garrett Lab is interested in defining the dynamic interactions between the mucosal immune system and gut microbiota. Our experimental questions are grounded in understanding how interactions between intestinal microbial communities and the immune...
The gamma-herpesvirus Epstein Barr virus (EBV) is a master regulator of B-cell biology. EBV persistently infects >95% of adults, making it one of the most successful viruses worldwide. While EBV typically establishes a safe balance with the host, it is...
Efferent Auditory Brainstem Circuits
Our laboratory has focused on auditory brainstem circuits that control the middle ear muscle reflexes, one of two major descending systems that provide feedback to the auditory periphery. Collaborating with M...
Mutational processes in cancer and normal cells; development of computational methods for genome and epigenome analysis.
We employ computational and statistical approaches to study various types of somatic mutations that arise in cancer cells and neurons...
Sialic acid O-acetylation, Siglecs and the regulation of hematopoiesis and immunity We are particularly interested in a novel set of pathways in which Sialic acid acetyl esterase (SIAE) and inhibitory receptors of the Siglec family regulate adaptive...
Title: Using protein engineering, antibody evolution and small-molecule discovery to dissect host-pathogen interactions
Key words: Protein engineering, viral evolution, host-pathogen interactions, small-molecule discovery
Our research focuses on the...
We investigate the mechanisms underlying germline maintenance and accurate chromosome inheritance during meiosis. Addressing this is of vital importance in order to understand the sources of errors that result in infertility, miscarriages, birth defects...