Our research is devoted to understanding the regulation of neuronal connectivity and synaptogenesis. We combine genetic approaches with molecular biology, sophisticated imaging, and behavioral assays to understand the cell biological mechanisms necessary...
Mutational processes in cancer and normal cells; development of computational methods for genome and epigenome analysis.
We employ computational and statistical approaches to study various types of somatic mutations that arise in cancer cells and neurons...
Sialic acid O-acetylation, Siglecs and the regulation of hematopoiesis and immunity We are particularly interested in a novel set of pathways in which Sialic acid acetyl esterase (SIAE) and inhibitory receptors of the Siglec family regulate adaptive...
We investigate the mechanisms underlying germline maintenance and accurate chromosome inheritance during meiosis. Addressing this is of vital importance in order to understand the sources of errors that result in infertility, miscarriages, birth defects...
The Garrett Lab is interested in defining the dynamic interactions between the mucosal immune system and gut microbiota. Our experimental questions are grounded in understanding how interactions between intestinal microbial communities and the immune...
The gamma-herpesvirus Epstein Barr virus (EBV) is a master regulator of B-cell biology. EBV persistently infects >95% of adults, making it one of the most successful viruses worldwide. While EBV typically establishes a safe balance with the host, it is...
In our lab in the Department of Neurobiology at Harvard Medical School, we worked for many years with non-human primates (NHPs) on a wide variety of questions, including neuronal mechanisms of attention, inference and flexible coding in parietal cortex...
The goal of our laboratory is to understand the mechanisms that underlie synaptic plasticity in the developing and mature mammalian central nervous system. We use a combination of tools, including electrophysiological, in vitro and in vivo optical...