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Although numerous eukaryotic genomes have been sequenced, much still remains to be understood about how the genes in those genomes are regulated. The interactions between transcription factors (TFs) and their DNA binding sites are an integral part of the...

Dr. Pardis Sabeti is an Associate Professor at the Center for Systems Biology and Department of Organismic and Evolutionary Biology at Harvard University and the Department of Immunology and Infectious Disease at the Harvard School of Public Health, and...

Our research group studies the statistical genetics of Mendelian disorders. We focus on two major application areas: methods to assess the pathogenicity of genomic variants and the clinical application of predictive algorithms in genomics. These...

Why is it easier to find out what experience shoppers worldwide have had with the latest digital camera than it is to determine what adverse events patients have had with a particular drug? Why are blood tests and X-rays repeated needlessly? Why can one...

The overall goal of our work is to solve biological problems using quantitative methods from bioinformatics, statistical physics, data sciences, statistics, computer science, and mathematics. We apply these computational methods to build predictive...

My lab studies the interplay between the gut microbiome and the immune system and how their “miscues” can lead to autoimmune diseases, particularly type 1 diabetes. As a 2013 BBS grad, I understand what it takes to have a successful Ph.D. experience.

The...

My research program focuses on the integration of "omic" approaches for the identification of new protein targets and small-molecule modulators of malignancy with an eye toward clinical translation. Cancer discovery efforts in my laboratory have focused...

A geneticist, molecular biologist and mathematician, Eric Lander is the Founding Director of the Broad Institute of Harvard and MIT, as well as a professor of Systems Biology at Harvard Medical School and a Professor of Biology at MIT. He pioneered the...

Our laboratory utilizes human genetic approaches to gain insight into blood cell production (hematopoiesis) and how this process is perturbed in disease states. We study rare genetic blood disorders and the genetics underlying variation in hematopoiesis...

Our research goal is to characterize genomic variation and functional change associated with human disease using a computational genomics and bioinformatic approach. Currently, we focus on investigating aberrations in repetitive DNA, particularly...