BBS

The O’Donnell-Luria laboratory studies how genetic variation contributes to the development of rare disease in humans. While individually rare, these conditions collectively affect ~5% of the population. Half of patients remain undiagnosed after clinical...

Multicellular organisms are formed by a large number of cell types, which serve as the components of tissues and organs. In the Simoes-Costa Lab, we study how cellular diversity arises during vertebrate embryonic development. We employ systems-level...

Taekjip Ha analyzes single molecules to understand how they act in complex biological systems. Ha and his team combine sophisticated biophysical manipulation techniques with fluorescence imaging to visualize and manipulate protein, RNA, and DNA molecules...

We are a collaborative group of genome editing scientists at the Translational Neuroscience Center of Boston Children’s Hospital and Harvard Medical School department of Neurology. We strive to develop gene-based therapeutics for genetic neurological...

Our longstanding interest is to study the molecular, cellular and genetic basis underlying cell function, differentiation and crosstalk in skeletal development, homeostasis, disease and repair. The skeleton, is a very dynamic tissue where the...

The Cantley laboratory explores the biochemical mechanism by which alterations in protein and lipid kinases drive cancer growth and survival and the development of inhibitors of these pathways for treating cancer.

The heart, like all internal organs, has its own local mini-brain. Nerve cells designed to sense the microenvironment connect to other neurons and to heart muscle and to pacemaker cells. This circuit sends signals to the brain and, in turn, is regulated...

Most proteins function by first binding a ligand, such as another protein, peptide, or small molecule. The Polizzi laboratory aims to learn the rules of protein–ligand binding through the lens of de novo protein design. In de novo design, a protein’s...

Certain basic cognitive processes are central to navigating the world around us. Attention, for example is important for almost all of our conscious actions, yet there's so much we still don't know about the cell types and circuits that support it...

My laboratory uses genetic, molecular and cellular approaches to investigate critical roles of cell signaling in mammalian embryonic morphogenesis, and homeostatic maintenance of adult tissues, particularly in the skeleton, dental-craniofacial system and...