The bithorax complex in the fruit fly is a cluster of “homeotic” genes which confer distinct identities on the different segments of the fly. The genes are strikingly aligned on the DNA in the order of the segments they affect. Many of the interactions...
We are interested in understanding the physical basis of how biological systems work at the nanoscale, with a focus on the role of mechanical force. More specifically, we investigate how force regulates the structure and dynamics of interactions between...
Recent advances in genomics now make it possible to consider enumerating all of the genetic lesions in specific cancers. High throughput approaches are already beginning to deployed to catalog the mutations present in specific cancers. While these...
The Pu laboratory studies cardiovascular development and disease, with a goal of developing new therapies for pediatric heart disease. We integrate molecular biology, functional genomics, cardiac physiology, genome editing, stem cell biology...
The long-term goal of Sellers lab is to deeply investigate cancer dependent genes to inform therapeutic discovery in cancer. The approaches to this problem have taken three forms. First, while at the Dana-Farber Cancer Institute and Broad Institute...
William Shih is a Professor in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and the Department of Cancer Biology at the Dana-Farber Cancer Institute and a Founding Core Faculty member at the Wyss Institute...
The Gu Lab focuses on elucidating how cells regulate proteasomal degradation independently of ubiquitination. We discovered a non-canonical proteolysis mechanism, the midnolin-proteasome pathway, that bypasses ubiquitination to selectively degrade...