Half of our genome consists of repeat sequences that resemble viral DNA, yet the functional significance of these virus-like repeats remains a mystery. Abnormal repeat sequences have been found at unstable genomic regions implicated in cancer and genetic...
The Gu Lab focuses on elucidating how cells regulate proteasomal degradation independently of ubiquitination. We discovered a non-canonical proteolysis mechanism, the midnolin-proteasome pathway, that bypasses ubiquitination to selectively degrade...
The Raghavan Lab at Dana-Farber Cancer Institute and Harvard Medical School is a basic and translational oncology lab focused on understanding mechanisms of cell state regulation in cancer, evaluating how cell state plasticity influences therapeutic...
The Lemieux laboratory investigates the pathogenesis and epidemiology tick-borne and respiratory pathogens using computational and experimental methods. Our primary focus is defining and characterizing the microbial genetic factors that influence Lyme...
The Abudayyeh-Gootenberg lab, based at the Mass General Brigham Gene and Cell Therapy Institute, Beth Israel Deaconess Medical Center, and Harvard Medical School, is dedicated to exploring programmable systems in biology for the development of molecular...
The Pu laboratory studies cardiovascular development and disease, with a goal of developing new therapies for pediatric heart disease. We integrate molecular biology, functional genomics, cardiac physiology, genome editing, stem cell biology...
My lab studies the development and evolution of cancer through analysis of intratumoral genetic, transcriptional, and immunological heterogeneity. Our work lies at the intersection of computational biology, molecular biology, and medicine: Using...
Our lab investigates aging and cancer with an emphasis on nuclear events. Our group discovered that the nucleus of a cell undergoes profound degeneration during aging and tumorigenesis. Our goal is to understand the mechanisms of nuclear degeneration and...