Our lab is focused on development and application of proteomics-based methods for in-depth analysis of key molecular events in tumorogenesis. Given the highly dynamic nature of biological processes, we are particularly interested in novel and robust...
Our lab works in the broad fields of T cell differentiation, immunological tolerance, autoimmunity and inflammation, translating mechanistic studies on mouse models to normal and diseased humans. Studies on T cell differentiation focus on maturation and...
The Mayadas laboratory is interested in understanding mechanisms of inflammation focusing both on the molecular basis of neutrophil recruitment, activation and function in autoimmune mediated diseases, and the endothelial dependent pathways regulating...
Recurrence of cancer in the form of metastatic disease accounts for more than 90% of cancer patient deaths; however, tumor metastasis is considered an inefficient process and disseminated tumor cells can remain indolent for long periods of time...
We are working to understand (i) how the human genome varies from person to person, and (ii) how inherited genome variation affects the biology of neurons and microglia on its way to affecting brain phenotypes such as risk of bipolar disorder, autism and...
The vast array of forms and functions exhibited by different cell types is made possible by the organization of specialized domains within the cell cortex. The overarching goal of our laboratory is to understand how the organization of protein complexes...
Synopsis of Research Interests:
The Amazing Success of Biological Auditory Systems
Humans routinely perform tasks with sound that remain impossible for even the most powerful and sophisticated machine hearing systems. Following a conversation on a noisy...
The Megason Lab uses imaging-based systems biology to elucidate the systems level principles of animal development. We are particularly interested in long standing problems in embryology whose understanding has defied molecular reduction namely...
Daryush Mehta is Director of the Voice Science and Technology Laboratory at the Massachusetts General Hospital Voice Center. Daryush is Associate Professor at Harvard Medical School, Affiliated Faculty and Director of Student Affairs in the Speech and...
Research in our laboratory focuses on the developmental biology of the pancreas. We wish to understand how the pancreas normally develops and use that information to grow and develop pancreatic cells (islets of Langerhans). One goal is to understand how...