The mission of the Greka laboratory is to define fundamental aspects of membrane protein biology and dissect mechanisms of cellular homeostasis. The laboratory complements this cell biology-focused program with tools from molecular biology, genomics...
The brain, which represents 2% of the body mass but consumes 20% of the body energy at rest, is therefore highly dependent on oxygen and nutrients supply from the blood stream. Key to the functional interdependence between neural and vascular systems is...
My laboratory is focused on understanding nervous system disease using molecular genetic strategies, beginning with human patients and proceeding through in vitro and modeling studies, with the ultimate goal of improving diagnosis, management and...
Technology drives biological research. A new technology can instantly provide answers that were difficult or impossible to address using current approaches. The emerging field of proteomics provides researchers an alternative/complementary strategy to...
Our laboratory is interested in the genetics of human cancer. Current projects include the use of a microfluidic device to capture circulating tumor cells (CTCs) and its application in molecular-directed therapy and in the study of human cancer...
The Hacohen lab consists of immunologists, geneticists, biochemists, technologists, physicians and computational biologists working together to develop new and unbiased technologies and strategies to understand basic immune processes and immune-mediated...
Recent advances in genomics now make it possible to consider enumerating all of the genetic lesions in specific cancers. High throughput approaches are already beginning to deployed to catalog the mutations present in specific cancers. While these...
Our laboratory studies diseases of the gastrointestinal tract, with emphasis on colorectal cancer (CRC) and inflammatory bowel disease (IBD). We use both conventional and systems biology approaches to integrate studies of genetically engineered mouse...
Our laboratory focuses on understanding the role that mitochondria play in mammalian aging and disease. Mitochondria are dynamic organelles that provide cells with energy even during dramatic changes in diet, stress and development. Mitochondria are also...